The vast majority of SCCs are not serious if detected early and treated quickly. However, squamous cell carcinoma can grow quickly and can be resistant to treatment or locally aggressive, damaging healthy skin around it, sometimes even reaching into bone and cartilage. With delays in treatment, it may be difficult to eliminate, and could result in disfigurement.

Squamous cell carcinomas that are at high risk for metastasis are usually found on the lip, ear, nose, or in persons who are immunocompromised. Speak with your Brevard Skin and Cancer Center physician about your treatment options.

An elevated growth with a central depression that occasionally bleeds. A growth of this type may rapidly increase in size.

An open sore that bleeds and crusts and persists for weeks.

A persistent, scaly red patch with irregular borders that sometimes crusts or bleeds.

A wart-like growth that crusts and occasionally bleeds.

Squamous Cell

Squamous cell carcinoma (SCC) is the second most common form of skin cancer, with over 250,000 new cases per year estimated in the U.S.. It arises in the squamous cells that compose most of the upper layer of the skin.

Most SCCs are not serious. When identified early and treated promptly, the future is bright. However, if overlooked, they are harder to treat and can cause disfigurement. While 96 to 97 percent of SCCs are localized, the small percentage of remaining cases can spread to distant organs and become life-threatening.


Chronic overexposure to the sun is the primary cause of most cases of squamous cell carcinoma. Tumors appear most frequently on the sun-exposed face, neck, bald scalp, hands, shoulders, arms, and back. The rim of the ear and the lower lip are especially vulnerable to these cancers.

SCCs may also occur where skin has suffered certain kinds of injury: burns, scars, long-standing sores, sites previously exposed to X-rays or certain chemicals (such as arsenic and petroleum by-products). In addition, chronic skin inflammation or medical conditions that suppress the immune system over an extended period of time may encourage development of the disease.

Occasionally, squamous cell carcinoma arises spontaneously on what appears to be normal, healthy, undamaged skin. Some researchers believe that a tendency to develop this cancer may be inherited.

Am I at risk?
Anyone with a substantial history of sun exposure can develop squamous cell carcinoma but certain environmental and genetic factors can increase the potential for this disease.

Sun Exposure
- Sunlight is responsible for over 90 percent of all skin cancers. Working primarily outdoors, living in an area that gets a lot of high intensity sunlight (like Australia), and spending time in tanning booths all increase your exposure to UV rays and thus increase your risk for developing skin cancer, including squamous cell carcinoma.

Skin Type
- People who have fair skin, light hair, and blue, green, or gray eyes are at highest risk. Hispanics, Asians and dark-skinned individuals of African descent are far less likely than Caucasians to develop skin cancer. Check out your skin type and how it affects your skin cancer risk.

Previous Skin Cancer
- Anyone who has had a skin cancer of any type is at increased risk of developing another one.

Reduced Immunity
- People with weakened immune systems due to excessive unprotected sun exposure, chemotherapy, or illnesses such as HIV/AIDS are more likely to develop squamous cell carcinoma.

Warning Signs
Squamous cell tumors are thick, rough, horny and shallow when they develop. Occasionally, they will ulcerate, which means that the epidermis above the cancer is not intact. There will be a raised border and a crusted surface over a raised, pebbly, granular base.

Any bump or open sore in areas of chronic inflammatory skin lesions indicates the possibility of squamous cell carcinoma, and a doctor should be consulted immediately if this is the case. Usually, the skin in these areas reveals telltale signs of sun damage, such as wrinkling, changes in pigmentation and loss of elasticity. That is why tumors appear most frequently on sun-exposed parts of the body.